Prospective Dutch CRC Cohort (PLCRC)





Start:  01 January 2021

End:  31 December 2024

Prospective Dutch CRC Cohort (PLCRC)

PLCRC is a population-based observational cohort study for all patients diagnosed with colorectal cancer (CRC) in the Netherlands.

The aim is to establish a continuous source for a large variety of research purposes. For this project, data will prospectively be collected on tumor characteristics, pathology results, medical history, comorbidities, medication use, basic physical examination, imaging results, treatment, treatment outcomes, hospital stays, interventions and grade 3/4 (serious) adverse events.

Participating patients will be invited on self-reported Health Related Quality of Life (HRQoL) and work ability, and to donate blood and tumor tissue samples for future research purposes. This cohort of colorectal cancer patients will further be used for other (future) studies, for example studies to evaluate the impact of diet and lifestyle on treatment response, or to evaluate new treatment modalities according to the cohort multiple randomized controlled trial design.

Patients: 9000
Study sites: 54


The increasing division in different tumor subtypes requires a new way of enrolling patients in trials. This is one of the reasons why the Prospective Dutch CRC cohort (PLCRC) was founded. This is an observational cohort study in which all patients with colorectal cancer can be enrolled. PLCRC aims to facilitate both national and international research to improve the outcomes of patients with colorectal carcinoma.

In order to make this possible, clinical data are retrieved from the Netherlands Cancer Registry, tumor tissue and blood are stored and patient reported outcomes are collected after informed consent of the patient. With the data and material, scientific research in the broadest sense can be carried out.

PLCRC is supported by the Dutch Colorectal Cancer Group (DCCG) and collaborates with various organizations like the Netherlands comprehensive cancer organisation (IKNL), BBMRI, Profiles, and many others.